Clinical Trial: Combined Use of Pulsed Dye Laser and Topical Antiangiogenic Agents for Treatment of Port Wine Stain Birthmarks

Study Status: Withdrawn
Recruit Status: Withdrawn
Study Type: Interventional

Official Title: Combined Use of Pulsed Dye Laser and Topical Antiangiogenic Agents for Treatment of Port Wine Stain Birthmarks

Brief Summary: The researcher want to improve port wine stain (PWS) therapeutic outcome in response to laser therapy. The researcher want to determine whether the combined use of pulsed dye laser (PDL) therapy and topical tacrolimus or pimecrolimus will improve PWS therapeutic outcome.

Detailed Summary:

Both topical agents inhibit nuclear factor of activated T-cells (NFAT) which blocks the calcineurin/NFAT pathway inhibiting endothelial cell proliferation and angiogenesis, which could be very useful in preventing PWS recanalization.

The combined use of PDL to induce PWS blood vessel injury, and topical antiangiogenic agents to prevent PWS blood vessel angiogenesis and recanalization after laser therapy, will improve PWS lesion blanching.

Sponsor: University of California, Irvine

Current Primary Outcome: Improve PWS lesion blanching. [ Time Frame: 8 weeks ]

Original Primary Outcome: Same as current

Current Secondary Outcome: To determine whether the combined use of pulsed dye laser (PDL) therapy and topical agent will improve PWS outcome. [ Time Frame: 8 weeks ]

Original Secondary Outcome: Same as current

Information By: University of California, Irvine

Dates:
Date Received: August 31, 2009
Date Started: November 2009
Date Completion:
Last Updated: February 8, 2017
Last Verified: February 2017