Clinical Trial: Intrinsic PEEP During Mechanical Ventilation of Patients With Obesity

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Intrinsic PEEP During Mechanical Ventilation of Patients With Obesity. Influence of Low Respiratory Rate With Unchanged Minute Volume.

Brief Summary: It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEP) is present in grossly obese subjects especially in the supine position. The investigators tried to investigate the effect of low respiratory rate and high tidal volume on the intrinsic PEEP and gas exchange for obese subjects undergoing general anesthesia.

Detailed Summary:

Impaired gas exchange is a common anesthetic problem in obese subjects. It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEPi) is present in grossly obese subjects especially in the supine position. It is known that there is a significant negative correlation between PEEPi present and PaO2. Therefore, the investigators postulated that if the reduce the PEEPi by reducing the respiratory rate in obese subjects, the impaired gas exchange might improve.

The investigators tried to research the effect of low respiratory rate and high tidal volume on the intrinsic PEEP and gas exchange for obese subjects undergoing general anesthesia.


Sponsor: Seoul Medical Center

Current Primary Outcome: Gas change parameters [ Time Frame: 15 minute interval ]

PaO2 and PaCO2 the result of arterial blood gas analysis


Original Primary Outcome: Same as current

Current Secondary Outcome: intrinsic positive end-expiratory pressure [ Time Frame: every 15 minutes ]

PEEPi measured by expiratory port occlusion method


Original Secondary Outcome: Same as current

Information By: Seoul Medical Center

Dates:
Date Received: December 28, 2010
Date Started: January 2011
Date Completion:
Last Updated: January 29, 2012
Last Verified: January 2012