Clinical Trial: Estimation of Intrinsic Positive End-Expiratory Pressure (PEEP) in Acute Respiratory Distress Syndrome (ARDS)

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Estimation of Intrinsic Positive End-Expiratory Pressure (PEEP) in Acute Respiratory Distress Syndrome (ARDS)

Brief Summary:

ARDS (Acute Respiratory Distress Syndrome) is a condition of severe inflammation and excess fluids in the lungs that impairs their function of oxygen uptake to the point of needing a ventilator (breathing machine) to help them obtain enough oxygen into the body. Because of the high amounts of gas that the ventilator has to give to these patients, high pressures may develop deep into the lungs and produce complications for the patient. However, physicians sometimes cannot recognize it because it requires special equipment to measure pressure deep in the lungs. The goal of this study is to determine if the amount of this pressure can be calculated using mathematical formulas and the routine numbers provided by ventilators. The study consists on making the conventional measurement of this deep pressure and at the same time calculate this same pressure from other measurements that the ventilator routinely provides, to see if the calculated value can replace the more complicated conventional measurement. The measurements will be done by:

  1. placing a small device along the tubing connecting the patient to the ventilator;
  2. giving medicines to relax the muscles (if the patient is not already receiving them); and
  3. making the ventilator hold the patient's breath for a few seconds to take measurements.

This is repeated after the breathing rate of the ventilator is increased or decreased mildly. Risks related to the medicine to be used and the measuring maneuvers are rare but include transient narrowing of windpipes, transiently low heart rate, blood pressure or blood oxygen, and allergic reactions. This is not a treatment. The information obtained during the study will be shared with the treating doctors who may find it useful to

Detailed Summary: Intrinsic PEEP (Positive-End Expiratory Pressure) was measured by end-expiratory occlusion method and estimated using formulas derived from measured expiratory flows and a postulated linear pressure-flow relationship during expiration in passive ARDS patients. Agreement between measured and estimated intrinsic PEEP was analyzed by Bland and Altman's method.
Sponsor: Texas Tech University Health Sciences Center, El Paso

Current Primary Outcome: Agreement between Measured and Estimated Intrinsic PEEP [ Time Frame: The day and time of measurement ]

Bias and its standard deviation


Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Texas Tech University Health Sciences Center, El Paso

Dates:
Date Received: March 12, 2007
Date Started: January 2004
Date Completion:
Last Updated: May 5, 2017
Last Verified: May 2017