Clinical Trial: Titrated Versus High and Low Dose Nebulized Morphine to Reduce Pain in Emergency Settings

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Efficacy and Safety of Nebulized Morphine Given at Two Different Doses Compared to Intravenous Morphine in Post-traumatic Acute Pain: a Randomized Controlled Double Blind Study

Brief Summary:

The investigators test a different technique using morphine to improve pain relief in patient visiting the emergency department with acute trauma pain, for this we are comparing three different methods of morphine administration:

  • intravenous titrated morphine
  • low dose nebulized morphine and
  • high dose nebulized morphine

Detailed Summary:

Trauma patients are frequent in emergency department settings, and often require urgent care.

taking care of this patients consists on taking care of their pain and then the specific treatment of their traumatic lesions.

actually, the most used medicine and most efficient one in treating pain is morphine, it's mechanism of action is by acting on receptors located on neuronal cell membranes and inhibit neurotransmitter release.

The most applied administration root of morphine is by intravenous (IV) titration or IV continuous perfusion, but until now, there is no clear recommendation concerning the superiority of this root over other administration techniques such as nebulization.

In this study we aimed to investigate the efficiency, the feasibility and the tolerance of three morphine administration roots in patients with acute traumatic pain and to clarify the most adequate one to apply in emergency department settings.


Sponsor: University of Monastir

Current Primary Outcome: Pain resolution [ Time Frame: 30 minutes ]

primary end point defined by the decrease in intensity pain objectified by a decline in visual analogy pain scale greater than or equal to 50% of its initial value


Original Primary Outcome: Same as current

Current Secondary Outcome: side effects [ Time Frame: 30 minutes ]

secondary outcomes combine the occurrence of side effects requiring discontinuation of treatment such as: dizziness, dyspnea, cutaneous rush, vomiting, nausea and pruritus.


Original Secondary Outcome: Same as current

Information By: University of Monastir

Dates:
Date Received: July 22, 2014
Date Started: April 2012
Date Completion:
Last Updated: November 26, 2014
Last Verified: November 2014