Clinical Trial: Can Tranexamic Acid Reduce Bleeding After Post Partum Hemorrhage in Cesarean Section Delivery

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effects of Tranexamic Acid on Post Partum Hemorrhage by Uterine Atony After Cesarean Section Delivery: a Randomized, Placebo Controlled Trial.

Brief Summary:

The purpose of this study was to evaluate the effect of early administration of tranexamic acid (TXA) on post partum hemorrhage caused by uterine atony after cesarean section delivery.

This was a randomised, placebo controlled trial including 74 patients. The investigators included ASA1 parturients with correct haemostatic status undergoing cesarean section under spinal anesthesia. The randomization begins after the inefficacy of oxytocin injections and starting up sulprostone perfusion at the request of the surgeon. TXA Group received 10 mg/kg of tranexamic acid as induction dose within 12 minutes and 1mg/Kg/h as maintenance within the 2 following hours. Placebo Group received same volumes of normal saline. The investigators compared blood loss and transfusions in both groups.

Detailed Summary:
Sponsor: Hédi Chaker Hospital

Current Primary Outcome: volume blood loss [ Time Frame: within 5 days after delivery ]

Original Primary Outcome: Same as current

Current Secondary Outcome: transfusion rates. [ Time Frame: within 5 days after delivery ]

Original Secondary Outcome: Same as current

Information By: Hédi Chaker Hospital

Dates:
Date Received: May 14, 2012
Date Started: July 2011
Date Completion:
Last Updated: May 21, 2012
Last Verified: May 2012