Clinical Trial: Effect of Medical Treatment and Prognosis of Postural Orthostatic Tachycardia Syndrome (POTS)

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional

Official Title: Comparison of Effect of Propranolol, Bisoprolol, Pyridosgitmine in Postural Orthostatic Tachycardia Syndrome (POTS) and Prognosis After Medical Treatment

Brief Summary: The purpose of the study is to investigate effect of medical treatment and prognosis of Postural Orthostatic Tachycardia Syndrome (POTS)

Detailed Summary:

Many patients who complained of dizziness are eventually diagnosed as POTS. However, the investigation of an appropriate medical treatment of POTS has not been enough yet. Also, the prognosis of the disease after treatment is not well known. It is known that propranolol attenuate the tachycardia and improve symptom burden in patients with POTS. However, the effect of other β-Blocker, bisoprolol compared with propranolol is not known well. In addition, acetylcholinesterase inhibition with pyridostigmine was a effective method of acutely decreasing the tachycardia in patients with POTS. However, difference among three medical treatments effect is not known and long-term studies are not done yet. Therefore, in this study investigator investigate effect of medical treatment (propranolol only, bisoprolol only, propranolol+pyridostigmine, bisoprolol+pyridostigmine) and prognosis of Postural Orthostatic Tachycardia Syndrome.

Longer-term studies are needed to assess this promising therapy.


Sponsor: Seoul National University Hospital

Current Primary Outcome: The change of the subjective symptom survey result after 3-month medical treatment. [ Time Frame: 3 month after medical treatment ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Normalization of orthostatic BP-HR test after 6-month medical treatment. [ Time Frame: 6 month ]
  • The change of the subjective symptom after 6-month medical treatment. [ Time Frame: 6 month ]
  • Change of quality of life score after treatment [ Time Frame: 6 month ]
  • Change of depression score after treatment [ Time Frame: 6 month ]


Original Secondary Outcome: Same as current

Information By: Seoul National University Hospital

Dates:
Date Received: June 19, 2014
Date Started: March 2014
Date Completion: December 2016
Last Updated: April 14, 2016
Last Verified: April 2016