Clinical Trial: Studying RNA in Samples From Younger Patients With T-Cell Acute Lymphoblastic Leukemia
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Molecular Taxonomy in Pediatric Cancer- IncRNA Expression in Primary T-ALL
Brief Summary:
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer
PURPOSE: This laboratory study is looking into RNA in samples from younger patients with T-cell (T) acute lymphoblastic leukemia (ALL).
Detailed Summary:
OBJECTIVES:
- Characterization of the transcriptomic landscape in diagnosis and relapse of T-cell acute lymphoblastic leukemia (ALL) and the direct comparison with corresponding physiological samples (human thymus).
- Perform high-throughput transcriptome ribonucleic acid (RNA) sequencing using matched diagnostic T-precursor pediatric ALL samples (peripheral blood or bone marrow).
OUTLINE: Archived peripheral blood and bone marrow samples are analyzed for long non-coding RNA (IncRNA) expression and sequencing.
Sponsor: Children's Oncology Group
Current Primary Outcome: Identification and characterization of IncRNA of pediatric T-cell acute lymphoblastic leukemia
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Children's Oncology Group
Dates:
Date Received: June 20, 2012
Date Started: May 2012
Date Completion:
Last Updated: May 13, 2016
Last Verified: May 2016
