Clinical Trial: Systematic Search for Primary Immunodeficiency in Adults With Infections

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Systematic Search for Primary Immunodeficiency in Adults With Unexplained Recurrent and/or Severe Infections With Encapsulated Bacteria

Brief Summary: Antibody deficiencies and complement deficiencies are the most frequent Primary immunodeficiencies (PIDs) in adults, and are associated with greatly increased susceptibility to recurrent and/or severe bacterial infections - especially upper and lower respiratory tract infections and meningitis. The literature data suggest that PIDs are under-diagnosed in adults. The current European and US guidelines advocate screening adults for PIDs if they present recurrent benign especially upper and lower respiratory tract infections, or if they have experienced at least two severe bacterial infections and/or have a recurrent need for intravenous antibiotics. The objective of the demonstrate the interest of PIDs screening in adult patients who present such recurrent infections and/or after the first severe bacterial infection, especially when the patients do not present with known, etiologically relevant comorbidities.

Detailed Summary:
Sponsor: University Hospital, Lille

Current Primary Outcome: Frequency of Primary immunodeficiencies (PIDs) in adult patients with recurrent and/or severe bacterial infection with encapsulated bacteria [ Time Frame: At 6 months ]

Original Primary Outcome: Frequency of PIDs in adult patients whith recurrent and/or severe bactérial infection with encapsulated bacteria [ Time Frame: At 6 months ]

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University Hospital, Lille

Dates:
Date Received: November 21, 2016
Date Started: March 2015
Date Completion: March 2018
Last Updated: November 23, 2016
Last Verified: November 2016