Clinical Trial: Heart Transplant and Primary Transplant Dysfunction: a Retrospective Analysis of the Strasbourg Experience

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Heart Transplant and Primary Transplant Dysfunction: a Retrospective Analysis of the Strasbourg Experience

Brief Summary:

Among the complications of heart transplant, primary dysfunction of the graft (PDG) is the most feared with a net impact on early morbidity and mortality. The all-cause mortality rate at the international level is 10% at 30 days and 34% at one year. Mortality at 30 days is secondary in 66% of cases with DPG or multi-organ failure.

The treatment of choice for the more severe PDG remains ECMO-type circulatory mechanical assistance or ventricular assistance. According to several studies, this could reduce early mortality. Early placement and short-term (<30 days) of support appear to improve survival in the first year after transplantation.

The haemodynamic parameters revealing this DPG are not clearly described in the literature.

hypothesis of this research is that:

  • DPG risk factors in strasbourg's hospital center are comparable to other European and international centers.
  • Simple hemodynamic parameters can be used to detect PDG earlier in order to set up assistance more quickly.
  • DPG risk factors in investigator's center are comparable to other European and international centers.
  • Simple hemodynamic parameters can be used to detect DPG earlier in order to set up assistance faster

Detailed Summary:
Sponsor: University Hospital, Strasbourg, France

Current Primary Outcome: Retrospective comparison of risk factors (incidence for ordinal and average variables for numerical variables) between patients suffering from severe primary dysfunction of the graft and those not suffering from severe primary dysfunction of the graft [ Time Frame: 1 month after leaving the operating room ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University Hospital, Strasbourg, France

Dates:
Date Received: January 4, 2017
Date Started: January 1, 2017
Date Completion: January 1, 2018
Last Updated: May 16, 2017
Last Verified: May 2017