Clinical Trial: Muscle Ultrasound Measures as Biomarkers of Upper Motor Neuron Function

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: A Pilot Study of Muscle Ultrasound Measures as Biomarkers of Upper Motor Neuron Function

Brief Summary:

Background:

- Primary lateral sclerosis (PLS) is a rare disease. It leads to weakness in the muscle of the arms, legs, and face. People with PLS develop muscle stiffness called spasticity. Researchers want to find a better way to measure this. They want to see if ultrasound, which uses sound waves to look at parts of the body, can measure spasticity and stiffness in muscles.

Objective:

- To see if ultrasound can detect and measure muscle spasticity in people with PLS.

Eligibility:

• People ages 18 75 who have a diagnosis of PLS and are enrolled in protocol 01-N-0145.
• Healthy volunteers ages 18 75.

Design:

• Participants with PLS will have 1 study visit. Healthy participants will have upto 5 visits. Each visit will be about 2 hours.
• Participants will have tests of muscle strength. They will be examined. They will push their arms and legs against researchers in different positions.
• Participants will have tests of muscle stiffness. Their arms and legs will be moved while they relax.
• Participants will have a muscle ultrasound test. They will lie on a table. Gel will be placed on the skin over the muscles of the arms and legs. A probe, like a microphone, will be moved over the skin. Researchers will look at several muscles.
• Participants should try to stay still during the ultrasound. It may be done several times and may be done by different exam
  

  Detailed Summary:

  Objective

  Persons with corticospinal, or upper motor neuron dysfunction have increased muscle stiffness from spasticity. Spasticity is established by clinical examination, but there are few reliable objective measures of spasticity. New ultrasound techniques to measure the elastic properties of tissue represent a potential measure of spasticity. The ultrasound measures of tissue elasticity are painless and quick to perform, but their ability to detect changes resulting from spasticity is uncertain. The goal of this pilot study is to see how much ultrasound measures of muscle elasticity differ between patients with spasticity and healthy controls. Secondary objectives are to correlate muscle elasticity measures with a clinical rating scale of spasticity and to assess intra and inter-rater reliability. This is a protocol for primary lateral sclerosis (PLS) patients who are enrolled in another NIH study in which they have been diagnosed with spasticity.

  Study Population

  23 adult PLS patients with arm or leg spasticity currently enrolled in an NIH protocol

  30 healthy adult controls with normal neurological exams.

  Design

  The first phase, an investigator training phase, is aimed to become familiar with the Siemens Acuson S2000 after the upgrade. The two investigators will train with 5 healthy volunteers. In the second phase inter-observer variability of the ultrasound and Ashworth scale will be assessed by having healthy volunteers and patients evaluated by the different investigators. Since spasticity does fluctuate throughout the day, subjects will be consecutively assessed for inter-observer variability and within a few hours or
  Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
  

  Current Primary Outcome: The primary outcome will be measuring muscle stiffness from the biceps brachii using ultrasound elastography, which will be compared between patient groups and control groups. [ Time Frame: 2 years ]
  
  

  Original Primary Outcome: Same as current
  
  

  Current Secondary Outcome: A secondary outcome will be the correlation of muscle stiffness at rest with the modified Ashworth score for elbow flexion. [ Time Frame: 2 years ]
  
  

  Original Secondary Outcome: Same as current
  
  Information By: National Institutes of Health Clinical Center (CC)
  

  Dates:
  Date Received: April 3, 2015
  Date Started: March 25, 2015
  Date Completion:
  Last Updated: April 21, 2017
  Last Verified: August 3, 2015