Clinical Trial: Yttrium Y 90 Glass Microspheres PET/CT in Imaging Patients With Liver Tumors
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: High Quality Imaging and Dosimetry of Yttrium-90 (90Y) SIRT Using a Digital PET/CT
Brief Summary: This clinical trial studies how well yttrium Y 90 glass microspheres positron emission tomography (PET)/computed tomography (CT) works in imaging patients with liver tumors. Images produced by PET/CT may provide better information about the distribution of particles, such as yttrium Y 90 glass microspheres, delivered for selective internal radiation therapy (SIRT) compared to the technetium Tc-99m albumin aggregated single photon emission computed tomography (SPECT)/CT images.
Detailed Summary:
PRIMARY OBJECTIVES:
I. To evaluate the image quality of yttrium Y 90 glass microspheres (90Y) PET/CT post SIRT images as compared to technetium Tc-99m albumin aggregated (99mTc MAA) SPECT/CT.
SECONDARY OBJECTIVES:
I. To determine the superior accuracy in both distribution and dosimetry of 90Y PET/CT post SIRT imaging compared to 99mTc MAA planar and SPECT/CT imaging.
OUTLINE:
Immediately after standard of care SIRT, patients receive yttrium Y 90 glass microspheres and undergo PET/CT over 30 minutes.
Sponsor: Stanford University
Current Primary Outcome: Image quality of lesions detected with PET/CT assessed by 5-point Likert scale [ Time Frame: Up to 1 month ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Radiopharmaceutical distribution and dosimetry accuracy of 90Y PET/CT [ Time Frame: Up to 1 month ]
Original Secondary Outcome: Same as current
Information By: Stanford University
Dates:
Date Received: April 6, 2017
Date Started: February 15, 2017
Date Completion: February 15, 2020
Last Updated: April 6, 2017
Last Verified: April 2017