Clinical Trial: Turner Syndrome Prenatal Diagnosis Study

Study Status: Terminated
Recruit Status: Unknown status
Study Type: Observational

Official Title: National Collaborative Study of Girls Prenatally Diagnosed With Turner Syndrome Karyotypes

Brief Summary: The goal of this study is to compare the features of Turner syndrome in girls who are diagnosed before birth because of fetal concerns versus those who are diagnosed when their mother has an amniocentesis for another reason.

Detailed Summary:

This is an observational study which will look at girls who are diagnosed with Turner syndrome before they are born. Girls will be divided into two groups: 1) those diagnosed because of features seen on ultrasound which raised the question of Turner syndrome and 2) those diagnosed incidentally when their mother had an amniocentesis for another reason such as advanced maternal age.

No clinical procedures nor interventions will be done as part of this data collection study which will occur for the first 3 to 6 years of the girl's life. The investigators will be looking to see if girls who are diagnosed incidentally have less features of Turner syndrome than those girls who are diagnosed because of fetal ultrasound.


Sponsor: Seattle Children's Hospital

Current Primary Outcome: Number of signs of Turner syndrome [ Time Frame: three to six years ]

Girls diagnosed with Turner syndrome by fetal ascertainment will have more signs of Turner syndrome than girls diagnosed by maternal ascertainment


Original Primary Outcome: Same as current

Current Secondary Outcome: Growth [ Time Frame: three to six years ]

Do girls with Turner syndrome ascertained by fetal ascertainment grow differently than girls ascertained by maternal ascertainment.


Original Secondary Outcome: Same as current

Information By: Seattle Children's Hospital

Dates:
Date Received: November 3, 2011
Date Started: January 2006
Date Completion: January 2017
Last Updated: August 14, 2012
Last Verified: August 2012