Clinical Trial: Risk of Diabetes in Young Turner Syndrome Patients

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Beta-Cell Function in Young Turner Syndrome Patients

Brief Summary: Turner Syndrome is a common genetic disorder. Seventy percent of adults with Turner Syndrome have abnormalities in glucose metabolism which can lead to diabetes. The current screening guidelines for diabetes in Turner Syndrome are not specific and involve a fasting blood sugar once a year. The objective of this study is to determine if there are abnormalities in glucose metabolism and pancreatic function in young girls with Turner Syndrome. The study hypothesis is that pancreatic dysfunction (specifically of the beta cells that make insulin) is more prevalent in girls with Turner Syndrome compared to healthy controls.

Detailed Summary: The study will be conducted at Children's Hospital Medical Center, Cincinnati. The study will require 1 visit to the hospital where the subject will have an oral glucose tolerance test and a physical exam
Sponsor: Children's Hospital Medical Center, Cincinnati

Current Primary Outcome: Beta-Cell Function measured as Disposition Index [ Time Frame: 1 day at screening ]

Disposition index will be calculated based on the results of the oral glucose tolerance test using minimal modeling (computer program)


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Children's Hospital Medical Center, Cincinnati

Dates:
Date Received: June 4, 2014
Date Started: May 2014
Date Completion: December 2015
Last Updated: September 25, 2015
Last Verified: September 2015