Clinical Trial: X-Chromosome Inactivation Status and Premature Ovarian Failure

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: X-Chromosome Inactivation Status and Premature Ovarian Failure

Brief Summary: Women who are affected with premature ovarian failure will exhibit skewed X-chromosome inactivation patterns compared to women with normal menstrual function (as defined by being pregnant), indicating a possible X-chromosome defect.

Detailed Summary:

Premature ovarian failure (POF) affects approximately 1% of women. For most women a cause is not found, but structural abnormalities of the X-chromosome commonly lead to POF, suggesting genes on the X-chromosome are necessary for normal ovarian function. It is known that certain gene mutations on the X-chromosome can lead to changes in the normal random pattern of X-chromosome inactivation in females.

We propose to study X-inactivation patterns in a cohort of women with idiopathic POF, and compare their pattern to a mean age-matched cohort of women with normal menstrual function.

We hypothesize that some women with POF will show skewed X-inactivation, suggesting a mutation on the X-chromosome as the etiology of their POF.

Sponsor: University of Pittsburgh

Current Primary Outcome: Skewed X-Inactivation appears increased in women with Premature Ovarian Failure [ Time Frame: 4 years ]

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Pittsburgh

Dates:
Date Received: February 17, 2006
Date Started: November 2005
Date Completion:
Last Updated: December 5, 2014
Last Verified: December 2014