Clinical Trial: Diagnosing Frontotemporal Lobar Degeneration
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Multimodal Assessment For Predicting Specific Pathological Substrate in Frontotemporal Lobar Degeneration
Brief Summary: To establish diagnostic tools to make an accurate clinical and pathological diagnosis of patients with clinical FTLD syndromes
Detailed Summary: The goal of this study is to determine the best diagnostic test for diagnosing frontotemporal lobar degeneration. To accomplish this, the current study will evaluate different tests: brain imaging, skin biopsy, body fluid samples (blood and cerebrospinal fluid), thinking abilities, everyday functioning, and brain autopsy. The study team hopes that this information can be used to guide diagnosis and further understanding of mechanism of disease in Frontotemporal Lobar Degeneration and possibly treatment in the future.
Sponsor: University Health Network, Toronto
Current Primary Outcome:
- Structural and Functional Diffferences between the FTLD groups via MRI of the brain [ Time Frame: One time visit through study completion of 5 years ]Differences in brain volumes and resting state functional connectivity
- Differences between the FTLD groups via PET imaging of the brain [ Time Frame: One time visit through study completion of 5 years ]Differences in ligand uptake
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: University Health Network, Toronto
Dates:
Date Received: September 23, 2016
Date Started: August 2015
Date Completion: December 2019
Last Updated: November 10, 2016
Last Verified: November 2016
