Clinical Trial: Minocycline in Primary Sclerosing Cholangitis (PSC)

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Open Label Pilot Study Evaluating Minocycline in Patients With Primary Sclerosing Cholangitis (PSC)

Brief Summary: The purpose of the study is to see how safe and effective minocycline is in the treatment of Primary Sclerosing Cholangitis (PSC).

Detailed Summary: The purpose of the study is to determine the safety profile of minocycline in patients with PSC and to compare the effects of minocycline on the baseline values of the following parameters: symptoms of pruritus and fatigue, liver biochemistries, Mayo Risk Score, the development of clinical progression and complications of liver disease.
Sponsor: Mayo Clinic

Current Primary Outcome: To evaluate the safety and estimate the efficacy at the maximally tolerated dose, 100 mg BID, in 30 patients with PSC. [ Time Frame: 1 year ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Mayo Clinic

Dates:
Date Received: February 27, 2008
Date Started: February 2003
Date Completion:
Last Updated: December 3, 2010
Last Verified: December 2010