Clinical Trial: Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Evaluation of Effectiveness and Safety of Oral Vancomycin in Treatment of Primary Sclerosing Cholangitis.

Brief Summary:

Primary sclerotic cholangitis (PSC) is an inflammatory process of sclerotic cholangitis that involves intra and extra hepatic biliary system. There is no curative treatment for this disorder. Supportive and conservative treatments are the most common therapies that used for this disease. Although treatments such as ursodeoxycholic acid (UDCA) are recommended in some situations but whereas a hypothesis is stimulatory effect of intestinal anaerobic bacteria such as cholestridium difficile as pathogenesıs of PSC, so use of antibiotics is recommended for treatment of these patients. Therefore according to the great role of anaerobic bacteria such as cholestridium difficile in pathogenesis, antibiotics such as metronidazole and vancomycin can be counted as recommended therapies in PSC. In addition some studies correlated this effect of vancomycin to its immunomudulatory effect the cause reduction of inflammation in biliary system. But with all this detail there is no finality about effectiveness of antibiotic therapy and accordingly in this study the investigators compare oral vancomycin effect versus placebo in primary sclerosing cholangitis patients.

In this double blind clinical trial 30 primary sclerosing cholangitis patients that divided in two 15 persosns group with Block Randomization method. in this study one group receive 250 mg oral vancomycin every 6 hours and other group receive placebo.

The study duration is 12 weeks . The baseline laboratory tests and 1 month and 3 months after treatment concept of; Alkaline phosphatase, ALT, AST, GGT and serum total bilirubin and clinical manifestations such as tiredness, itching and probable adverse effects such as hypotension accompanied by flushing,erythematous rash on face and upper body (red neck or red man syndrome), chills and drug fever, eosinophilia and reversible n

Detailed Summary:
Sponsor: Tehran University of Medical Sciences

Current Primary Outcome:

  • comparison of laboratory data Alkalyne phosphatase between baseline and after treatment [ Time Frame: 12 weeks ]
    Alkaline phosphatase
  • comparison of laboratory data ALT between baseline and after treatment [ Time Frame: 12 weeks ]
    ALT
  • comparison of laboratory data AST between baseline and after treatment [ Time Frame: 12 weeks ]
    AST
  • comparison of laboratory data GGT between baseline and after treatment [ Time Frame: 12 weeks ]
    GGT
  • comparison of laboratory data serum total bilirubin between baseline and after treatment [ Time Frame: 12 weeks ]
    serum total bilirubin
  • baseline data [ Time Frame: baseline ]
    serum Albumin


Original Primary Outcome: Same as current

Current Secondary Outcome: Number of participants with adverse events [ Time Frame: 12 weeks ]

clinical manifestations such as tiredness, itching and probable adverse effects such as hypotension accompanied by flushing,erythematous rash on face and upper body (red neck or red man syndrome), chills and drug fever, eosinophilia and reversible neutropenia.


Original Secondary Outcome: Same as current

Information By: Tehran University of Medical Sciences

Dates:
Date Received: October 31, 2015
Date Started: September 2015
Date Completion: February 2016
Last Updated: November 11, 2015
Last Verified: November 2015