Clinical Trial: Pleural Abrasion Plus Minocycline Versus Apical Pleurectomy for Primary Spontaneous Pneumothorax

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Comparison of Pleural Abrasion Plus Minocycline Pleurodesis Versus Apical Pleurectomy After Thoracoscopic Bullectomy for High Recurrent Risk Patients With Primary Spontaneous Pne

Brief Summary: Optimal surgical management of primary spontaneous pneumothorax has been a matter of devate, especially regarding the method of pleurodesis. Previous studies have shown that thoracoscopic apical pleurectomy is a reliable method with a very low incidence of recurrence. However, this procedure is more technical demanding and time consuming through thoracoscopy. In addition, a more extensive pleural injury may cause impaired pulmonary function and a higher risk of perioperative complication such as hemothorax. In our previous studies, we have shown that thoracoscopic pleural abrasion with minocycline instillation is an easy and convinent method of pleurodesis which decreases the rate of recurrence without affecting pulmonary function. In this study, we hypothesized that pleural abrasion with minocycline instillation is as effective as apical pleurectomy in preventing pneumothorax recurrence while the short-term and long-term complications are less.

Detailed Summary: Optimal surgical management of primary spontaneous pneumothorax has been a matter of devate, especially regarding the method of pleurodesis. Previous studies have shown that thoracoscopic apical pleurectomy is a reliable method with a very low incidence of recurrence. However, this procedure is more technical demanding and time consuming through thoracoscopy. In addition, a more extensive pleural injury may cause impaired pulmonary function and a higher risk of perioperative complication such as hemothorax. In our previous studies, we have shown that thoracoscopic pleural abrasion with minocycline instillation is an easy and convinent method of pleurodesis which decreases the rate of recurrence without affecting pulmonary function. In this study, we hypothesized that pleural abrasion with minocycline instillation is as effective as apical pleurectomy in preventing pneumothorax recurrence while the short-term and long-term complications are less.
Sponsor: National Taiwan University Hospital

Current Primary Outcome: Recurrence rate of pneumothorax after thoracoscopic operation.

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • The short-term results (Pain level, chest tube duration, hospital stay, etc)
  • Complication rate
  • Long-term results: residual pain
  • Long-term pulmonary function test


Original Secondary Outcome:

  • 1. The short-term results (Pain level, chest tube duration, hospital stay, etc)
  • 2. Complication rate
  • 3. Long-term results: residual pain
  • 4. Long-term pulmonary function test


Information By: National Taiwan University Hospital

Dates:
Date Received: December 26, 2005
Date Started: April 2005
Date Completion: May 2009
Last Updated: August 4, 2006
Last Verified: August 2006