Clinical Trial: Turmeric Effect on Reduction of Serum Prolactin and Related Hormonal Change and Adenoma Size in Prolactinoma Patients

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title:

Brief Summary: Prolactinoma is the most prevalent anterior hypophysis tumor. The principal treatment for this disorder is Dopamine agonist drugs including bromocriptin and Cabergoline. However, 50% of Bromocriptin treated and 17% of Cabergoline treated patients are resistant to these drugs. Curcumin is the main derivative of turmeric ,an old spice which is used frequently in Indian and Iranian cuisine. It has been proved that curcumin can reduce mammotrope cells proliferation and also intracellular hormone production. The purpose of this study is to evaluate the effect of turmeric on prolactinoma patients.

Detailed Summary:
Sponsor: Mashhad University of Medical Sciences

Current Primary Outcome: serum prolactin level [ Time Frame: 2weeks and one month after treatment ]

Original Primary Outcome: Same as current

Current Secondary Outcome: change in LH,FSH and estradiol from baseline [ Time Frame: one month ofter treatment ]

Original Secondary Outcome: Same as current

Information By: Mashhad University of Medical Sciences

Dates:
Date Received: April 18, 2011
Date Started: July 2011
Date Completion: August 2012
Last Updated: October 29, 2011
Last Verified: October 2011