Clinical Trial: Dosing of Antibiotics During Reimplantation of Infected Knee and Hip Prostheses
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Dosing of Antibiotics (Serum and Periprosthetic Tissues) During Reimplantation of Infected Knee and Hip Prostheses
Brief Summary: The purpose of the study is to evaluate the concentrations of antibiotics used as empirical treatment in serum and periprosthetic tissues during reimplantation of infected hip and knee prostheses
Detailed Summary: The purpose of the study is to evaluate the concentrations of antibiotics (daptomycin, vancomycin, cefotaxime, ceftriaxone, cefepime) in serum and periprosthetic tissues(bone and synovial joint) used as empirical treatment during reimplantation of infected hip and knee prostheses (1-stage or 2-stage management).
Sponsor: Tourcoing Hospital
Current Primary Outcome: Primary outcome measure was the evaluation of concentrations in serum and periprosthetic tissues of antibiotic agents used as empirical therapy during reimplantation of the infected prosthesis [ Time Frame: 1 day ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Secondary outcome will analyze the ratio of antibiotic concentration in serum and prosthetic tissues to minimum inhibitory concentration of the concerned antibiotic for the pathogen(s) identified in intraoperative samples [ Time Frame: 1 day ]
Original Secondary Outcome: Same as current
Information By: Tourcoing Hospital
Dates:
Date Received: August 5, 2016
Date Started: August 2016
Date Completion: August 2017
Last Updated: August 5, 2016
Last Verified: August 2016