Clinical Trial: Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation

Brief Summary: This study evaluates the influence of the taste sensitivity, of food preferences and of the reward system on the energetic balance before and after liver transplantation in cirrhotic patients and after kidney transplantation in renal failure patients

Detailed Summary:

Background and Aims: Protein-energy malnutrition is associated to cirrhosis with a high prevalence and greatly increases the morbidity and mortality of the disease. Malnutrition results of numerous causes including intestinal malabsorption, increased energy resting expenditure, metabolism disturbances, impaired sensory taste and changes in food preferences which might participate to a reduction in food intake. The aim of this study was to determine the relationships that may exist between taste sensitivity and food preferences on the one hand, eating habits, nutritional status, energy balance and biological parameters including amino acids on the other hand in patients with end-stage cirrhosis and in patients with renal failure.

Fifteen end-stage cirrhotic patients and 15 renal failure patients will be included and matched with 30 healthy subjects. The following parameters will be evaluated during a morning testing session: gustatory sensitivity using a triangular detection threshold method for sweet, salty and umami solutions; preferences for fat- and carbohydrate-rich foods using the PrefQuest score; liking for six foods (protein-, carbohydrate- and fat-rich foods) and wanting for 18 foods (photographs); hunger sensation; energy intake (24 h ingested food); body composition (BMI and impedancemetry); resting energy expenditure (indirect calorimetry) and physical activity (questionnaire). Several plasmatic parameters (amino-acids, leptin, ghrelin, lipid profile) will be also determined.


Sponsor: University of Burgundy

Current Primary Outcome:

  • Energy expenditure [ Time Frame: two years ]
    evice: indirect calorimetry (sensormedics)
  • body composition [ Time Frame: 2 years ]
    Device: Multifrequency bio-impedancemetry (aminostats)
  • amino acids profil in plasma [ Time Frame: 2 years ]
    Biological measurments
  • Food preferences [ Time Frame: 2 years ]
    Device: Treshold taste detection


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Burgundy

Dates:
Date Received: October 3, 2016
Date Started: May 2014
Date Completion: December 2017
Last Updated: October 10, 2016
Last Verified: October 2016