Clinical Trial: Efficacy and Safety of Losartan in Pediatric Chronic Kidney Disease With Tubular Proteinuria
Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Interventional
Official Title: A Prospective, Randomized, Cross-over Study Evaluating the Efficacy and Safety of Losartan in Pediatric Chronic Kidney Disease With Tubular Proteinuria
Brief Summary: The investigators hypothesize that using Losartan would help decrease proteinuria in pediatric chronic kidney disease with tubular proteinuria.
Detailed Summary:
Sponsor: Seoul National University Hospital
Current Primary Outcome: the change in urinary protein-creatinine ratio from baseline to the end of 12 weeks [ Time Frame: 12 weeks ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- the change in urinary albumin-creatinine ratio from baseline to the end of study [ Time Frame: 12 weeks ]
- the proportion of patients wifh more than 50% decrease of urinary protein-creatinine ratio [ Time Frame: 12 weeks ]
- the change in urinary beta2-microglobulin-creatinine ratio from baseline to the end of study [ Time Frame: 12 weeks ]
- the change in urinary NAG-creatinine ratio from baseline to the end of study [ Time Frame: 12 weeks ]
Original Secondary Outcome: Same as current
Information By: Seoul National University Hospital
Dates:
Date Received: September 3, 2014
Date Started: September 2014
Date Completion: November 2016
Last Updated: September 3, 2014
Last Verified: September 2014