Clinical Trial: The Impact of Hormone Therapy on Lower Urinary Tract Symptoms, Sexual Function and Psychosomatic Disorder

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: The Impact of Different Hormone Therapy Regimens on Lower Urinary Tract Symptoms, Sexual Function and Psychosomatic Disorder

Brief Summary:

Menopausal syndromes includes somatic symptom, psychosomatic symptoms, sexual dysfunction and even urinary symptoms. Hormone therapy (HT) is widely used for controlling menopausal symptoms. Common HT for menopausal syndrome with intact uterus includes tibolone, estradiol valerate (E2V) 1mg & medroxyprogesterone acetate (MPA) 2.5 mg, and conjugated equine estrogens & MPA.

However, only a few literatures mentioned about the therapeutic effect of tibolone, but lack of comparison research about their therapeutic effect on somatic symptoms, psychosomatic symptoms, sexual dysfunction and even urinary symptoms. The knowledge of the above therapeutic effects should be important for choosing a suitable medication. Therefore, the aim of this study is to assess the therapeutic effect on somatic symptoms, psychosomatic symptoms, sexual dysfunction and even urinary symptoms between tibolone and E2V/MPA.


Detailed Summary:
Sponsor: Far Eastern Memorial Hospital

Current Primary Outcome: Menopausal symptoms [ Time Frame: 12 weeks ]

To clarify any difference of reduction in menopausal symptom scores between these two groups


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • sexual function [ Time Frame: 12 weeks ]
    To clarify any difference of improvements of sexual function scores between these two groups
  • lower urinary tract symptoms [ Time Frame: 12 weeks ]
    To clarify any difference of improvements of lower urinary tract symptoms scores between these two groups
  • psychosomatic symptoms [ Time Frame: 12 weeks ]
    To clarify any difference of improvements of psychosomatic symptoms scores between these two groups


Original Secondary Outcome: Same as current

Information By: Far Eastern Memorial Hospital

Dates:
Date Received: November 26, 2012
Date Started: December 2012
Date Completion: June 2019
Last Updated: February 9, 2017
Last Verified: September 2016