Clinical Trial: Susceptibility to High Altitude Pulmonary Edema in Subjects With Increased Hypoxic Pulmonary Vasoconstriction
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Susceptibility to High Altitude Pulmonary Edema in Subjects With Increased Pulmonary Artery Pressure During Exercise in Normoxia and at Rest in Hypoxia
Brief Summary: It has been shown, that subjects susceptible to high altitude pulmonary edema (HAPE)are characterized by an abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia. This abnormal rise of pulmonary artery pressure has also been observed in about 10 % of otherwise healthy subjects without prior altitude exposure. The aim of the study is to investigate the susceptibility to HAPE in unacclimatized subjects with abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia after rapid ascent to high altitude (4559 m).
Detailed Summary:
Sponsor: Heidelberg University
Current Primary Outcome: Frequency of HAPE after rapid ascent to 4559 m [ Time Frame: during the 48 h stay at altitude ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Time course of pulmonary artery pressure [ Time Frame: during the 48 h stay at altitude ]
- Assessment of right ventricular function by echocardiography [ Time Frame: during the 48 h stay at altitude ]
Original Secondary Outcome: Same as current
Information By: Heidelberg University
Dates:
Date Received: November 15, 2007
Date Started: June 2007
Date Completion:
Last Updated: September 5, 2013
Last Verified: November 2007
