Clinical Trial: Ketorolac Premedication for Anesthetic Efficiency of IANB & Postendodontic Pain in Teeth With Irreversible Pulpitis

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Effect of Ketorolac Premedication on Anesthetic Efficiency of Inferior Alveolar Nerve Block, Pre-Treatment and Post-Endodontic Pain in Teeth With Irreversible Pulpitis: A

Brief Summary: The aim of this study to assess effect of ketorolac premedication on the effectiveness of the inferior alveolar nerve block, pretreatment and postoperative pain in patients with symptomatic irreversible pulpitis.

Detailed Summary:

  • Patients will be clinically and radiographically examined and their eligibility will be assessed and preoperative pain will be measured. Eligible patients will be treated in one visit.
  • Patients will be randomly assigned to one of 2 groups: experimental group (taking a 10 mg tablet of ketorolac) and the control group (taking a placebo tablet). Each tablet will be taken one hour before starting treatment. The patient's pain will be assessed before local anesthetic adminstration. After 15 minutes of the initial inferior alveolar nerve block (IANB), the teeth will be examined using a cold pulp sensitivity test; in case of no or mild pain, the treatment will be initiated.
  • During root canal treatment, no to mild pain response will be considered success. In case of failure, supplemental anesthesia will be administrated.
  • Postoperative pain will be assessed 6, 12, 24 and 48 hours after treatment. The number of patients who will require rescue analgesic medication within the 48 hours postoperatively will be counted.

Sponsor: Cairo University

Current Primary Outcome: Anesthetic efficiency [ Time Frame: Intraoperative (During endodontic treatment) ]

Pain during endodontic treatment will be assessed using a numerical rating scale (NRS). No or mild pain response will be considered success.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Postoperative pain [ Time Frame: At 6,12, 24, 48 hours after root canal treatment ]
    Postoperative pain will be measured using a numerical rating scale (NRS)
  • Number of patients requiring rescue analgesic. [ Time Frame: Within 48 hours after endodontic treatment ]
    Number of patients requiring rescue analgesic within 48 hours after endodontic treatment


Original Secondary Outcome: Same as current

Information By: Cairo University

Dates:
Date Received: October 19, 2016
Date Started: January 2017
Date Completion: January 2018
Last Updated: October 20, 2016
Last Verified: October 2016