Clinical Trial: Pupillary Dilation Reflex (PDR) Evaluation During General Anesthesia
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Pupillary Dilation Reflex (PDR) Evaluation During General Anesthesia: a Pilot Study
Brief Summary: In this study, the pupillary dilation reflex is measured as a nociceptive indicator during elective abdominal surgery under general anesthesia.
Detailed Summary: An infrared camera of the video pupillometer measures the pupillary dilation reflex (PDR) in response of a nociceptive stimulus. This autonomic reflex, parasympathetic mediated in sedated patients, can be generated by various pain stimuli (built in standardized protocol, surgical incision, …) The PDR is a robust reflex, even in patients under general anesthesia, and provides a potential evaluation of the autonomous circuit within the nociceptive evaluation based on pupil dilation upon A-delta and C fibers in both electrical or mechanic stimulation. This mono-centric project involving American Society of Anesthesiologists (ASA) classification I-II patients undergoing elective abdominal surgery under general anesthesia are recruited. Enrolled patients perioperative undergo PDR measurements at four different standardized times.
Sponsor: University Hospital, Antwerp
Current Primary Outcome: Pupillary Reflex Dilation [ Time Frame: Perioperative phase ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Patient Movement [ Time Frame: Perioperative phase ]Patient movement during surgery as a common used indicator for pain
- Vital signs [ Time Frame: Perioperative phase ]Increased vital signs (heart rate, blood pressure) during surgery as a common used indicator for pain
Original Secondary Outcome: Same as current
Information By: University Hospital, Antwerp
Dates:
Date Received: October 20, 2016
Date Started: October 2016
Date Completion:
Last Updated: May 5, 2017
Last Verified: May 2017