Clinical Trial: Intra-arterial Thrombolysis for Severe Recent Central Retinal Vein Occlusion
Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional
Official Title: Phase 1 Trial of Intra-Ophthalmic Artery Thrombolysis for Treating Recent Severe Central Retinal Vein Occlusion
Brief Summary:
- Study hypothesis: Injection of t-PA, a thrombolytic drug (clot busting medicine)into the ophthalmic artery (the blood vessel feeding the eye), in patients with recent severe central retinal vein occlusion, may reopen the central retinal vein and improve retinal blood flow, which may in turn improve visual acuity and prevent the long-term complications of the disease.
- Experimental intervention: An outpatient procedure during which the ophthalmic artery is selective catheterized (with a small plastic tube called a microcatheter introduced from the artery of the leg) and infused with t-PA during two hours.
Detailed Summary:
Sponsor: Weill Medical College of Cornell University
Current Primary Outcome: Improvement of retinal perfusion on the 1-week fluorescein angiogram, with no severe complications. [ Time Frame: One week ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Number of patients with 3 or more lines of visual acuity improvement during follow up. [ Time Frame: 6 months ]
Original Secondary Outcome: Same as current
Information By: Weill Medical College of Cornell University
Dates:
Date Received: April 12, 2012
Date Started: January 2012
Date Completion: January 2015
Last Updated: April 18, 2012
Last Verified: April 2012
