Clinical Trial: Study of the Implication of Omega-3 Polyunsaturated Fatty Acids in Retinopathy of Prematurity in New-born Infants

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Study of the Implication of Omega-3 Polyunsaturated Fatty Acids in Retinopathy of Prematurity in Newborns

Brief Summary: The development of the retinal vascular network is generally complete during the 3rd trimester of pregnancy but may continue during the first 15 days of life. This late maturation may cause problems in pre-term births and may result in immature vascularization of the retina, a condition called retinopathy of prematurity. Among the different factors affecting the development of the retinal vasculature, the tissue level of omega-3 polyunsaturated fatty acids (PUFA) appears to be a crucial element, as does the form of the PUFA present in the tissues (nature of the phospholipids in their membranes). This project aims to show a possible association between levels of omega-3 PUFA and the onset of retinopathy of prematurity (ROP).

Detailed Summary:
Sponsor: Centre Hospitalier Universitaire Dijon

Current Primary Outcome: Stage of retinopathy of prematurity using a Retcam according to the ICROP classification (International Classification of Retinopathy of Prematurity) revised in 2005. [ Time Frame: At 4 weeks of life or 31 weeks of amenorrhea ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Concentrations of omega-3 PUFA in Red Blood Cell (RBC) membranes. [ Time Frame: At inclusion ]

Original Secondary Outcome: Same as current

Information By: Centre Hospitalier Universitaire Dijon

Dates:
Date Received: June 29, 2016
Date Started: July 2015
Date Completion:
Last Updated: June 30, 2016
Last Verified: June 2016